What Is Rejuran and How Can It Benefit Your Skin?

Here at Amore Cosmetics, we've seen a growing interest in regenerative aesthetics. This exciting field focuses on encouraging your skin's natural ability to heal and repair itself, rather than simply masking signs of aging. Instead of just adding volume or temporarily plumping the skin, regenerative treatments like Rejuran work at a cellular level to restore your skin's quality, texture, and resilience over time.

Originally developed in South Korea, Rejuran has become incredibly popular due to its unique ingredient: polydeoxyribonucleotides (PDRN). This is a special form of salmon DNA extract that supports skin regeneration, deep hydration, and collagen production. But what exactly is PDRN, and how does it help your skin?

What Is PDRN and Why Is Salmon DNA Used?

PDRN (polydeoxyribonucleotide) is a DNA-derived compound crucial for cellular repair and regeneration. While it's not naturally found in human skin, it's made up of nucleotides—the fundamental building blocks of DNA and RNA, which are essential for tissue growth and healing.

Why Use Salmon DNA?

You might be surprised to hear about marine-derived DNA in skincare, but research shows that PDRN extracted from salmon sperm has a remarkable 96.5% similarity to human DNA. This close match allows your skin cells to recognize and respond to it, helping to trigger your natural repair mechanisms.

Originally studied for its wound-healing and anti-inflammatory properties, PDRN has been shown to:

• Promote skin regeneration by supporting cell turnover and collagen synthesis.
• Enhance hydration by strengthening your skin’s barrier.
• Reduce inflammation by helping to calm redness and irritation.

Unlike some regenerative ingredients derived from human tissue, salmon DNA is considered a safer and more sustainable alternative. The PDRN used in Rejuran is highly purified, ensuring that only the active, beneficial components are delivered to your skin.

How Does PDRN Work in the Skin?

PDRN acts as a biological messenger, stimulating your skin cells to repair and regenerate themselves. It works through three main mechanisms:

• Tissue Repair & Collagen Stimulation: PDRN activates fibroblasts, which are cells that boost collagen and elastin production. This helps to improve skin firmness, elasticity, and reduce the appearance of fine lines.
• Cell Turnover & Skin Renewal: It encourages the shedding of old, damaged skin cells and promotes the formation of new, healthy ones, leading to a smoother texture and a more even tone.
• Anti-Inflammatory & Hydration Boosting: PDRN helps reduce redness and irritation, while also reinforcing your skin’s moisture barrier, improving overall skin health and resilience.

To achieve these amazing results, the product needs to penetrate beyond the surface of the skin. While in some countries, Rejuran is given through injections, at Amore Cosmetics, we offer Rejuran exclusively as a topical solution. We apply it immediately after procedures that temporarily disrupt the skin barrier—such as microneedling, RF microneedling, or laser treatments. These microchannels allow for enhanced absorption of the active ingredients, ensuring the PDRN can reach deeper layers of your skin.

A Regenerative Alternative: Discover VAMP

For those looking to enhance their skin's recovery after treatments, VAMP offers a revitalizing solution that perfectly aligns with the principles of regenerative aesthetics. Designed to be applied topically after procedures like microneedling, RF microneedling, or laser treatments, VAMP delivers a rich blend of active ingredients that nourish the skin and support visible repair.

Its formula combines polydeoxyribonucleotides (PDRN) with hyaluronic acid and four key amino acids, including glycine and proline—two major building blocks of collagen. These components work together to improve hydration, support collagen and elastin production, and strengthen your skin’s barrier function.

By helping your skin recover more effectively after controlled micro-injury, VAMP contributes to a smoother, more radiant complexion. Whether used on its own or alongside other regenerative approaches, it offers a nutrient-dense boost tailored to support your skin’s natural healing process.

Beyond PDRN Salmon DNA Facial – Treatments That Support Your Skin from Within

If you’re looking to improve skin quality, boost collagen, and restore a youthful glow—without adding volume—regenerative treatments offer a natural way to enhance your skin from within. While Rejuran has gained attention for its skin-repairing properties, it is just one of many innovative regenerative options available today.

In the world of aesthetics, several authorized treatments work with your body’s natural processes to stimulate collagen production, accelerate skin renewal, and strengthen the skin barrier. From biostimulating injectables and PRP/PRF to exosome therapy and advanced laser treatments, regenerative aesthetics is redefining how we care for our skin, helping to improve texture, elasticity, and overall skin health over time.

Exosome Therapy

Exosomes are tiny messengers naturally produced by cells to transmit biological signals and regulate cellular communication. They play a key role in tissue repair, collagen production, and skin regeneration. However, as we age, this regenerative activity slows down, leading to loss of elasticity, hydration, and overall skin vitality.

In aesthetic medicine, exosomes used in treatments are purified from stem cell sources and applied topically after treatments that create microchannels, such as:

• Microneedling: Enhances absorption and stimulates skin renewal.
• Laser treatments: Supports tissue repair and improves skin tone.
• PRP (Platelet-Rich Plasma) therapy: Works synergistically to accelerate skin healing.

Because exosomes are naturally occurring messengers, they work with your body’s own processes to enhance recovery, reduce inflammation, and improve long-term skin health.

Biostimulating Injectables: Enhancing Skin Quality from Within

Unlike traditional fillers, biostimulating injectables don’t just add volume; they work by stimulating your skin’s natural collagen production and improving hydration, leading to firmer, more radiant skin over time. These treatments help restore skin density, elasticity, and hydration, making them a key part of regenerative aesthetics.

Collagen-Stimulating Injectables

As collagen production slows with age, the skin becomes thinner, less elastic, and more prone to wrinkles. Collagen stimulators work by activating fibroblasts, the cells responsible for producing collagen and elastin. Over time, they restore skin density, improve firmness, and reduce sagging, making them ideal for gradual, natural-looking rejuvenation.

Skin Boosters

For skin that lacks moisture, radiance, or elasticity, hyaluronic acid-based skin boosters deliver intense hydration directly into the skin’s deeper layers. Unlike traditional fillers, they don’t add volume but enhance water retention, improve skin texture, and create a lasting glow. By reinforcing the skin barrier and increasing cellular hydration, they help skin appear plumper, smoother, and more refreshed over time.

By stimulating collagen renewal and optimizing skin hydration from within, biostimulating injectables offer a long-term approach to healthier, firmer, and more youthful-looking skin without altering facial volume.

PRP (Platelet-Rich Plasma) & PRF (Platelet-Rich Fibrin)

PRP and PRF are regenerative treatments derived from your own blood, designed to stimulate collagen production, accelerate skin healing, and improve overall skin quality. These treatments work by isolating platelets and growth factors, which are then reintroduced into the skin to trigger natural repair and rejuvenation.

PRP (Platelet-Rich Plasma): A concentrated form of platelets and growth factors that stimulate collagen, improve skin texture, and enhance radiance.

PRF (Platelet-Rich Fibrin): A more advanced version of PRP, containing higher levels of growth factors and fibrin, which help promote longer-lasting regeneration and volume restoration.

Both treatments are highly effective for dull skin, fine lines, acne scars, and even hair restoration, offering a natural way to enhance skin health over time.

Laser & Energy-Based Skin Regeneration: Stimulating Repair from Within

Fractional laser treatments deliver precise energy into the skin, creating controlled micro-injuries that trigger the body’s natural healing response. As the skin repairs itself, collagen and elastin production increases, helping to improve firmness, smooth texture, and reduce the appearance of scars and pigmentation.

These treatments are particularly effective for softening fine lines, refining pores, and evening out skin tone. By working within the skin’s deeper layers, they stimulate long-term structural improvements, leading to a stronger, more resilient, and naturally rejuvenated complexion.

Finding the Right Approach for Your Skin

Regenerative aesthetics offer a range of solutions to restore skin quality, boost collagen, and enhance hydration, but the right treatment depends on your individual needs. Some people benefit from collagen stimulators to improve firmness and elasticity, while others may see better results with skin boosters for deep hydration or exosome and PRP/PRF therapies to accelerate skin healing and renewal.

The best way to determine what’s right for you is through a personalized consultation at Amore Cosmetics. Our skincare specialists can assess your skin concerns, discuss your goals, and create a customized treatment plan that aligns with your needs. Whether you’re looking to address fine lines, loss of elasticity, uneven texture, or overall skin vitality, our expert guidance can help you achieve natural, long-lasting results.

Are you ready to explore the benefits of regenerative skincare and discover a treatment that's perfect for you?